Physiologic Anemia
Jane A. Curtis MD1
1 Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY
Editors: Henry M. Adam, MD.
The changes in levels of hemoglobin and hematocrit in the first weeks of life are dramatic. O'Brien and Pearson, in a classic article, demonstrated that these levels drop from an average hemoglobin of 17 g/dL and a hematocrit of 52% in cord blood to a hemoglobin of 11.4 g/dL and a hematocrit of 33% at 75 days of age. The reasons for this drop and the physiologic mechanisms involved in causing it have fascinated a number of researchers.
When considering the results of blood values, the first step is to be sure of the validity of the measurements. Early researchers in this area, such as Oettinger and Mills, noted a wide range of quoted normal values for hemoglobin and hematocrit of the newborn.