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Serologic Tests: Utility in Clinical Pediatric Practice

Leonard R. Krilov MD1
 1 North Shore University Hospital, New York University School of Medicine, New York, NY

Despite clinical microbiologic advances in the isolation and/or detection of bacterial pathogens, determination of infection with a number of clinically important bacteria relies on serologic testing. When a reliable specific immunoglobulin (Ig) M test is available or when a significant (ie,ge4 fold) change in titer is obtained in acute and convalescent serologies, these tests can be used to make a definitive diagnosis. A single elevated titer in the face of a compatible clinical scenario also may help support a given diagnosis.

Infection with a number of infrequently encountered bacteria, when suspected, can be documented well by serologic testing. Examples include the primarily zoonotic organisms Brucella, Leptospira, and Francisella tularensis.






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