Pediatrics in Review
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(Pediatrics in Review. 1984;6:139-157.)
© 1984 American Academy of Pediatrics
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Benzyl Alcohol as Preservative for Intravenous Solutions

Benzyl alcohol is commonly used as an antibacterial agent in a variety of formulations including bacteriostatic sodium chloride and bacteriostatic water. Although benzyl alcohol toxicity has been recognized, the concentration necessary for antibacterial action appears to be much lower than the concentration that would be dangerous to adults. Prior to these reports, little was known about the toxic effects of benzyl alcohol in neonates.

The possible toxic effects of benzyl alcohol in neonates were noted when several premature infants in neonatal intensive care units developed similar clinical syndromes, referred to as the "gasping syndrome," characterized by deterioration of multiple organ systems and eventual death.






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Pediatrics Pediatrics in Review
Copyright © 1984 by the American Academy of Pediatrics.