Sarcoidosis
Sarcoidosis is a granulomatous disorder of undetermined cause involving multiple organs. The clinical picture varies with age. Hetherington reviewed 8 cases of sarcoidosis in children less than 4 years of age. The common presentations were rash (75%), arthritis (60%), and uveitis (60%). The rash was described as erythematous, maculosymptoms, papular, with slight scaling starting peripherally and then becoming generalized. Joint symptoms began with early morning stiffness, progressing to boggy, nondeforming, painless effusions and synovial thickening. Ocular changes included posterior synechiae, uveitis, optic atrophy, miliary retinitis, and granulomas of the conjunctivae and optic nerve. In contrast, Hetherington noted that in children more than 4 years of age pulmonary involvement was seen in 70%, lymphadenopathy in 45%, uveitis in 40%, and rash in 35%.
