Hypervitaminosis A
The uses of vitamin A have been increasing in recent years. It is currently used for treatment of acne, icthiosis, and other skin disorders. It has also been given in megavitamin dosages for treatment of patients with learning disabilities, and it is also self-administered for the prevention of colds and as part of megavitamin fadist diets.
It is important to recognize that there are significant complications from the use of vitamin A. These occur both from excessive acute single dosages (eg, ingestion of polar bear liver in Eskimos) and from chronic intake of low levels of vitamin A throughout a long period of time. The usual diet contains between 5,000 and 10,000 lU/d of vitamin A. Normal serum levels are usually less than 250 lU. Side effects have been reported with a chronic intake of as low as 20,000 to 50,000 IU/d for a period of 6 to 8 months.
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