Pediatrics in Review
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(Pediatrics in Review. 1997;18:107.)
© 1997 American Academy of Pediatrics

Management of Ibuprofen Overdose

Tina C. Zecca, DO, Chief Resident*
* Pediatrics CHNJ and NJMS Newark, NJ
Ibuprofen has become one of the most popular and widely used non-steroidal anti-inflammatory drugs (NSAIDs) since its introduction in the United States in 1974. This propionic acid derivative inhibits prostaglandin synthesis and possesses both analgesic and antipyretic properties. NSAIDs usually are absorbed rapidly after oral administration. Renal excretion usually is the primary route of elimination. Common side effects from NSAID use usually are due to potent inhibition of prostaglandin synthesis. These side effects include gastrointestinal (GI) irritation with dyspepsia, increased occult GI blood loss, GI bleeding, and possible peptic ulceration. All of these symptoms can be alleviated with the administration of nonabsorbable antacids and food. Elevation of transaminase levels as well as alkaline phosphatase also can occur.

Acute poisoning with NSAIDs does not result in significant morbidity and mortality, . . . [Full Text of this Article]






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