Pediatrics in Review
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(Pediatrics in Review. 1997;18:191. doi:10.1542/10.1542/pir.18-6-191)
© 1997 American Academy of Pediatrics
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Formula Intolerance

Richard H. Rapkin, MD*
* New Jersey Medical School Newark, NJ
Formula intolerance, also called adverse reaction to formula, encompasses a wide variety of pathogenetic mechanisms, including allergy. The latter has an immunologic basis. Formula intolerance may occur because of congenital or acquired enzyme deficiencies (eg, disaccharidase), ingestion of toxin or pharmacologic agents (eg, Staphylococcus aureus toxin), or true hypersensitivity that has a proven immunologic mechanism. Whatever the pathophysiology, the physician must try to determine objectively whether signs and symptoms reflect formula intolerance and, if so, which constituent of the formula may be the basis for the problem.

The signs and symptoms of formula intolerance are legion, involve many systems, and can be mimicked by other causes, some of which are minor variants . . . [Full Text of this Article]


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Copyright © 1997 by the American Academy of Pediatrics.