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(Pediatrics in Review. 1999;20:271-272.)
© 1999 American Academy of Pediatrics

Genital Warts

	OBJECTIVES

 
Upon completion of this article, readers should be able to:

1. Describe the frequency of HPV infection compared with all sexually transmitted diseases.
   
2. Describe what percent of sexually active female adolescents have tested positive for HPV DNA.
   
3. Name the HPV types that have been associated strongly with premalignant and malignant cervical carcinoma in females.
   

	Introduction

 
Genital warts or condyloma acuminata are caused by infection with human papillomavirus (HPV), a double-stranded DNA virus. Several types of HPV cause exophytic genital warts and subclinical infection of the vagina and cervix, including types 6, 11, 16, 18, 31, and 45. Types 16, 18, 31, and 45 have been associated strongly with premalignant and malignant cervical carcinoma in females. HPV-16 is responsible for about 50% of cervical cancers, and types 16, 18, 31, and 45 together account for 80% of cancers. Common warts are associated with different HPV types than those that cause genital warts.

	Epidemiology

 
HPV infection is becoming recognized as one of the most frequent of all sexually transmitted diseases; 18% to 33% of sexually active female adolescents have tested positive for HPV DNA in several studies. The causation of genital papillomas among children is less well studied, . . . [Full Text of this Article]

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