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(Pediatrics in Review. 2006;27:e81-e82.)
© 2006 American Academy of Pediatrics

In Brief

In Brief

Barbiturate Overdosage

The first 20% of the full text of this article appears below.

Barbiturates. Coupey SM. Pediatr Rev. 1997;18:260 –265[Free Full Text] Monitoring the Future: National Results on Adolescent Drug Use: Overview of Key Findings. Johnston LD, O’Malley PM, Bachman JG, et al. NIH Publication No. 05–5726. Bethesda, Md: National Institute on Drug Abuse; 2005 Barbiturates. In: Harvey RA, Champe PC, eds. Pharmacology. Philadelphia, Pa: JB Lippincott Company; 1992:96–98 Multiple-dose Activated Charcoal Compared to Urinary Alkalinization for the Enhancement of Phenobarbitol Elimination. Frenia ML, Schauben JL, Wears RL, et al. Clin Toxicol. 1996;34:169 –175

Barbiturates are physically addicting sedative-hypnotic agents that can cause severe withdrawal symptoms. Their original role was to treat anxiety and insomnia, but they became popular drugs of abuse in the 1960s and 1970s and the most commonly used drugs in suicide attempts. Use of barbiturates has decreased significantly with stricter governmental regulations and with the advent of the much safer benzodiazepines. Current therapeutic uses of barbiturates are to treat seizure disorders, headaches, gastrointestinal disorders, and increased intracranial pressure and for anesthesia induction, but they have no analgesic properties. Adolescents abuse barbiturates to achieve a euphoric "high," to offset the undesirable anxiety caused by stimulant drugs, and to attempt suicide.

Monitoring the Future is a national survey of high school students that investigates their use of . . . [Full Text of this Article]


Tahniat Syed, MD, MPH
Mario Cruz, MD
 Drexel University College of Medicine
St. Christopher's Hospital for Children
Philadelphia, Pa





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