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(Pediatrics in Review. 2007;28:37-38.)
© 2007 American Academy of Pediatrics

In Brief

Retinoblastoma

The first 20% of the full text of this article appears below.

Screening for Retinoblastoma: Presenting Signs as Prognosticators of Patient and Ocular Survival. Abramson DH, Beaverson K, Sangani P, et al. Pediatrics. 2003;112 :1248 –1255[Abstract/Free Full Text] Red Reflex Examination in Infants. American Academy of Pediatrics, Section on Ophthalmology. Pediatrics. 2002;109 :980 –981[Abstract/Free Full Text] Delayed Diagnosis of Retinoblastoma: Analysis of Degree, Cause, and Potential Consequences. Butros LJ, Abramson DH, Dunkel IJ. Pediatrics. 2002;109 :e45 . Available at: http://pediatrics.aappublications.org/cgi/content/full/109/3/e45[Abstract/Free Full Text] Retinoblastoma. Lohmann DR, Gallie BL. GeneReviews. 2005. Available at: http://www.genetests.org.

Retinoblastoma is a malignant tumor of the developing retina that usually occurs before 5 years of age. It is the most common pediatric eye tumor, occurring in about 1 in 20,000 children. When detected early, this embryonal tumor is among the most curable of childhood cancers. Early diagnosis and recognition of the possible genetic implications for the patient and family are important for optimal management and counseling. Delay in diagnosis can lead to the need for enucleation, central nervous system involvement, and hematogenous metastases.

Leukocoria, or a white pupillary reflex on the ophthalmoscopic "red reflex" test, is the most common presenting clinical finding, seen in 50% to 60% of cases of retinoblastoma. Parents are . . . [Full Text of this Article]


William G. Wilson, MD
 University of Virginia School of Medicine
Charlottesville, Va

Janet R. Serwint, MD, Consulting Editor, In Brief




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