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(Pediatrics in Review. 2007;28:397-398.)
© 2007 American Academy of Pediatrics

In Brief

Pharmacokinetics

The first 20% of the full text of this article appears below.

Pharmacologic Considerations in Antimicrobial Therapy, With Emphasis on Pharmacokinetics and Pharmacodynamics: Reviews for the Practicing Clinician. McKinnon PS, Yu VL. Eur J Clin Microbiol Infect Dis. 2004;23 :231 –232[CrossRef][Medline] Antibacterial Agents in Pediatrics. Bowlware KL, Stull T. Infect Dis Clin North Am. 2004;18 :513 –531[CrossRef][Medline] The Therapeutic Monitoring of Antimicrobial Agents. Begg EJ, Barclay ML, Kirkpatrick CJM. Br J Clin Pharmacol. 1999;47 :23 –30[CrossRef][Medline] Once- Versus Twice-daily Gentamicin Dosing in Neonates ≥ 34 Weeks’ Gestation: Cost-effectiveness Analyses. Thureen PJ, Reiter PD, Gresores A, Stolpman NM, Kawato K, Hall DM. Pediatrics. 1999;103 :594 –598[Abstract/Free Full Text]

Pharmacokinetics describes, in mathematical terms, what the body does to an administered drug: its absorption, distribution, metabolism, and elimination. A very important linked process, pharmacodynamics, describes what an administered drug does to microorganisms and to the body: its effects and toxicity. Awareness of these principles is essential in optimizing the efficacy of drug therapy while minimizing drug-related toxicity.

When considering antimicrobial agents, it is important to recognize several factors in pediatric patients that influence . . . [Full Text of this Article]


John M. Olsson, MD
 Brody School of Medicine East Carolina University Greenville, NC





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