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(Pediatrics in Review. 2009;30:30-31. doi:10.1542/10.1542/pir.30-1-30)
© 2009 American Academy of Pediatrics
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(Pediatrics in Review. 2009;30:30-31.)
© 2009 American Academy of Pediatrics

In Brief

Hematopoietic Growth Factors in Pediatric Patients

The first 20% of the full text of this article appears below.

Haemopoietic Growth Factors for Neonates: Assessing Risks and Benefits. Carr R, Modi N. Acta Paediatr Suppl. 2004;93 :15 –19[CrossRef][Medline] Erythropoietin after a Century of Research: Younger than Ever. Jelkmann W. Eur J Haematol. 2007;78 :183 –205[CrossRef][Medline] What is the Price of an Erythrocyte and Neutrophil? Kamen BA, Glod J. J Pediatr Hematol Oncol. 2004;26 :699 –700[CrossRef][Medline] Use of Epoetin and Darbepoetin in Patients with Cancer: 2007 American Society of Hematology/American Society of Clinical Oncology Clinical Practice Guideline Update. Rizzo JD, Somerfield MR, Hagerty KL, et al. Blood. 2008;111 :25 –41[Abstract/Free Full Text] The Role of Recombinant Erythropoietin in Childhood Cancer. Shankar AG. Oncologist. 2008;13 :157 –166[Abstract/Free Full Text] 2006 Update of Recommendations for the Use of White Blood Cell Growth Factors: An Evidence-based Clinical Practice Guideline. Smith TJ, Khatcheressian J, Lyman GH, et al. J Clin Oncol. 2006;24 :3187 –3205[Abstract/Free Full Text]

The presence of circulating hematopoietic growth factors (HGFs) was postulated more than 100 years ago, when it was noted that serum collected from rabbits 1 day after bloodletting would induce reticulocytosis and an increase in hematocrit when injected into healthy rabbits. Over the past century, collaborative bench, preclinical, and clinical research has resulted in the availability of recombinant HGFs capable of alleviating various cytopenias in patients who have absolute or relative deficiencies of the relevant endogenous growth factors. The two HGFs employed most commonly in clinical practice are erythropoietin-alpha (EPO) and granulocyte colony-stimulating factor (GCSF).

The glycoprotein hormone EPO is produced predominantly by kidney . . . [Full Text of this Article]


Peter D. Cole, MD
 Children's Hospital at Montefiore
Bronx, NY

Henry M. Adam, MD, Editor, In Brief
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