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- Ee Tein Tay, MD
- Albert Einstein College of Medicine
Children’s Hospital at Montefiore
Bronx, NY
Azole antifungals consist of two primary classes: imidazoles and triazoles. Both classes are fungistatic agents and share similar mechanisms of action. The azoles interfere with the synthesis and permeability of fungal cell membranes by inhibiting cytochrome P450-dependent 14-alpha-sterol demethylase. This enzyme is required for the synthesis of ergosterol, the major sterol of most fungal cell membranes. The loss of cell membrane integrity inhibits cell division by causing intracellular swelling and interferes with cellular adhesion and epithelial penetration by allowing the protrusion of cytoplasm through the membrane. Currently available imidazoles include clotrimazole, miconazole, ketoconazole, …
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