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American Academy of Pediatrics
In Brief

Hemolytic-Uremic Syndrome

Elizabeth K. Fiorino and Ryan M. Raffaelli
Pediatrics in Review October 2006, 27 (10) 398-399; DOI: https://doi.org/10.1542/pir.27-10-398
Elizabeth K. Fiorino
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  1. Elizabeth K. Fiorino, MD
  2. Ryan M. Raffaelli, MD
  1. Children’s Hospital at Montefiore
    Bronx, NY

Glomerular Disorders. Eddy A. In: Rudolph CD, ed. Rudolph’s Pediatrics. 21st ed. New York, NY: McGraw Hill; 2003:1677– 1699Escherichia coli O157:H7 and the Hemolytic-Uremic Syndrome. Boyce TG, Swerdlow DL, Griffin PM. N Engl J Med. 1995;333 :364– 368OpenUrlCrossRefPubMedEscherichia coli Diarrhea (Including Hemolytic-Uremic Syndrome). In: Pickering LK, ed. Red Book: 2006 Report of the Committee on Infectious Diseases. 27th ed. Elk Grove Village, Ill: American Academy of Pediatrics; 2006:291– 296Important Bacterial Gastrointestinal Pathogens in Children: A Pathogenesis Perspective. Amieva MR. Pediatr Clin North Am. 2005;52 :749– 777OpenUrlCrossRefPubMedHemolytic Uremic Syndrome: Pathogenesis, Treatment, and Outcome. Siegler R, Oakes R. Curr Opin Pediatr. 2005;17 :200– 204OpenUrlCrossRefPubMedRelative Nephroprotection During Escherichia coli O157:H7 Infections: Association With Intravenous Volume Expansion. Ake JA, Jelacic S, Ciol MA, et al. Pediatrics. 2005;115 :e673– e680OpenUrlAbstract/FREE Full Text

Hemolytic-uremic syndrome (HUS), the triad of microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency, is the leading cause of renal failure in the United States in previously healthy children, in particular those younger than 3 years of age. There are two broad etiologic categories: typical HUS (with diarrhea, or D+) and atypical HUS (without diarrhea, or D−). Some 90% of HUS in the United States is classified as D+, and most cases are caused by shiga-toxin-producing strains of Escherichia coli (STEC), most often the O157:H7 subtype.

Although E coli are part of the normal intestinal flora, the bacteria have acquired the ability to cause disease in the gastrointestinal (GI) tract. STEC, also called enterohemorrhagic E coli, is the only pathotype of E coli causing disease in children in the United States. The STEC pathotype is related closely to enteropathogenic E coli, the cause of traveler’s diarrhea, with …

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Pediatrics in Review: 27 (10)
Pediatrics in Review
Vol. 27, Issue 10
October 2006
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Hemolytic-Uremic Syndrome
Elizabeth K. Fiorino, Ryan M. Raffaelli
Pediatrics in Review Oct 2006, 27 (10) 398-399; DOI: 10.1542/pir.27-10-398

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Hemolytic-Uremic Syndrome
Elizabeth K. Fiorino, Ryan M. Raffaelli
Pediatrics in Review Oct 2006, 27 (10) 398-399; DOI: 10.1542/pir.27-10-398
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