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American Academy of Pediatrics
In Brief

Pharmacokinetics

John M. Olsson
Pediatrics in Review October 2007, 28 (10) 397-398; DOI: https://doi.org/10.1542/pir.28-10-397
John M. Olsson
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  1. John M. Olsson, MD
  1. Brody School of Medicine East Carolina University Greenville, NC

Pharmacologic Considerations in Antimicrobial Therapy, With Emphasis on Pharmacokinetics and Pharmacodynamics: Reviews for the Practicing Clinician. McKinnon PS, Yu VL. Eur J Clin Microbiol Infect Dis. 2004;23 :231– 232OpenUrlCrossRefPubMedAntibacterial Agents in Pediatrics. Bowlware KL, Stull T. Infect Dis Clin North Am. 2004;18 :513– 531OpenUrlCrossRefPubMedThe Therapeutic Monitoring of Antimicrobial Agents. Begg EJ, Barclay ML, Kirkpatrick CJM. Br J Clin Pharmacol. 1999;47 :23– 30OpenUrlCrossRefPubMedOnce- Versus Twice-daily Gentamicin Dosing in Neonates ≥ 34 Weeks’ Gestation: Cost-effectiveness Analyses. Thureen PJ, Reiter PD, Gresores A, Stolpman NM, Kawato K, Hall DM. Pediatrics. 1999;103 :594– 598OpenUrlAbstract/FREE Full Text

Pharmacokinetics describes, in mathematical terms, what the body does to an administered drug: its absorption, distribution, metabolism, and elimination. A very important linked process, pharmacodynamics, describes what an administered drug does to microorganisms and to the body: its effects and toxicity. Awareness of these principles is essential in optimizing the efficacy of drug therapy while minimizing drug-related toxicity.

When considering antimicrobial agents, it is important to recognize several factors in pediatric patients that …

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Pediatrics in Review: 28 (10)
Pediatrics in Review
Vol. 28, Issue 10
October 2007
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Pharmacokinetics
John M. Olsson
Pediatrics in Review Oct 2007, 28 (10) 397-398; DOI: 10.1542/pir.28-10-397

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Pharmacokinetics
John M. Olsson
Pediatrics in Review Oct 2007, 28 (10) 397-398; DOI: 10.1542/pir.28-10-397
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