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- John M. Olsson, MD
- Brody School of Medicine East Carolina University Greenville, NC
Pharmacokinetics describes, in mathematical terms, what the body does to an administered drug: its absorption, distribution, metabolism, and elimination. A very important linked process, pharmacodynamics, describes what an administered drug does to microorganisms and to the body: its effects and toxicity. Awareness of these principles is essential in optimizing the efficacy of drug therapy while minimizing drug-related toxicity.
When considering antimicrobial agents, it is important to recognize several factors in pediatric patients that …
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