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- Christine Briccetti, MD*
- Peter Rowe, MD*
- *Johns Hopkins University, Baltimore, MD.
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Author Disclosure
Drs Briccetti and Rowe have disclosed no financial relationships relevant to this article. This commentary does not contain a discussion of an unapproved/investigative use of a commercial product/device.
Case Study
You are evaluating a 5-day-old infant whose newborn screen was reported as positive for primary congenital hypothyroidism. While you await the results of his thyroid stimulating hormone (TSH) and thyroid assessment, the family asks you about the accuracy of the newborn screening. They want to know how likely it is that their baby has primary congenital hypothyroidism. How would you get the information needed to answer their questions?
Searching the Literature
MEDLINE is the National Library of Medicine's database of biomedical articles. PubMed (www.PubMed.org) is the free resource that is used most commonly to search the MEDLINE database. PubMed Clinical Queries (found under “PubMed Tools”) is a feature that can be accessed from the PubMed home page. This tool filters out information that is not likely to be useful clinically. Although not suited for extensive literature searches, this procedure is an excellent method to search for useful clinical information in a few minutes.
The first step is to decide what question or information to enter into the search engine to obtain the most useful results. One approach is to …
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