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American Academy of Pediatrics
Article

Pneumonia

Rani S. Gereige and Pablo Marcelo Laufer
Pediatrics in Review October 2013, 34 (10) 438-456; DOI: https://doi.org/10.1542/pir.34-10-438
Rani S. Gereige
*Editorial Board. Department of Medical Education, Miami Children’s Hospital, Miami, FL.
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Pablo Marcelo Laufer
†Division of Pediatric Infectious Diseases, Miami Children’s Hospital, Miami, FL.
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  1. Rani S. Gereige, MD, MPH*
  2. Pablo Marcelo Laufer, MD†
  1. *Editorial Board. Department of Medical Education, Miami Children’s Hospital, Miami, FL.
  2. †Division of Pediatric Infectious Diseases, Miami Children’s Hospital, Miami, FL.
  • Author Disclosure

    Drs Gereige and Laufer have disclosed no financial relationships relevant to this article. This commentary does not contain discussion of unapproved/investigative use of a commercial product/device.

  • Abbreviations:
    BAL:
    bronchoalveolar lavage
    CAP:
    community-acquired pneumonia
    CA-MRSA:
    community-associated methicillin-resistant Staphylococcus aureus
    ELISA:
    enzyme-linked immunosorbent assay
    HIV:
    human immunodeficiency virus
    hMPV:
    human metapneumovirus
    IGRA:
    interferon gamma release assay
    LRTI:
    lower respiratory tract infection
    MRSA:
    methicillin-resistant Staphylococcus aureus
    MSSA:
    methicillin-sensitive Staphylococcus aureus
    PCR:
    polymerase chain reaction
    RSV:
    respiratory syncytial virus
    VATS:
    video-assisted thoracoscopic surgery
    WHO:
    World Health Organization
  • Practice Gap

    The epidemiology of pneumonia is changing; chest radiographs and routine laboratory testing are unnecessary for routine diagnosis of community-acquired pneumonia in children who are candidates for outpatient treatment.

    Objectives

    The readers of this article are expected to:

    1. Know the cause, clinical manifestations, differential diagnosis, and general approach to the diagnosis, treatment, and prevention strategies of the different types of pneumonia in children of various age groups.

    2. Be aware of the challenges that face the clinician in making an accurate diagnosis of pneumonia due to the inaccuracies and shortcomings of the various laboratory and imaging studies.

    3. Know the complications of pneumonia in children and their appropriate diagnostic and therapeutic strategies.

    Introduction

    Pneumonia is commonly encountered by emergency department and primary care clinicians. Childhood pneumonia remains a significant cause of morbidity and mortality in developing countries, whereas mortality rates in the developed world have decreased secondary to new vaccines, antimicrobials, and advances in diagnostic and monitoring techniques. (1) This review focuses on pneumonia in children: its causes in various age groups, clinical manifestations, indications for hospitalization, and the challenges that clinicians face in making an accurate diagnosis despite the new and emerging diagnostic tests.

    Epidemiology

    The incidence of pneumonia varies by age groups and between developing and developed countries. Worldwide, the overall annual incidence of pneumonia in children younger than 5 years is 150 million to 156 million cases, (2)(3) leading to an estimated 2 million deaths per year, most of which occur in developing countries. (4) Forty percent of cases require hospitalization. (5) In developed countries, the annual incidence of pneumonia is estimated at 33 per 10,000 in children younger than 5 years and …

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    Pediatrics in Review: 34 (10)
    Pediatrics in Review
    Vol. 34, Issue 10
    1 Oct 2013
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    Pneumonia
    Rani S. Gereige, Pablo Marcelo Laufer
    Pediatrics in Review Oct 2013, 34 (10) 438-456; DOI: 10.1542/pir.34-10-438

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    Pneumonia
    Rani S. Gereige, Pablo Marcelo Laufer
    Pediatrics in Review Oct 2013, 34 (10) 438-456; DOI: 10.1542/pir.34-10-438
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