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Case 6: Failure to Thrive with Congenital Glaucoma in a 2-month-old Girl

Brittney Statler, David J. Massop and John W. Schmidt
Pediatrics in Review April 2017, 38 (4) 189-190; DOI: https://doi.org/10.1542/pir.2016-0132
Brittney Statler
*Division of Ophthalmology, Surgical Department, Brown University, Providence, RI
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David J. Massop
†Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX
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John W. Schmidt
‡Division of Newborn Medicine, Creighton University Medical Center, Omaha, NE
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  1. Brittney Statler, MD*
  2. David J. Massop, MD†
  3. John W. Schmidt, MD‡
  1. *Division of Ophthalmology, Surgical Department, Brown University, Providence, RI
  2. †Department of Ophthalmology, University of Texas Health Science Center at San Antonio, San Antonio, TX
  3. ‡Division of Newborn Medicine, Creighton University Medical Center, Omaha, NE
  • AUTHOR DISCLOSURE

    Drs Statler, Massop, and Schmidt have disclosed no financial relationships relevant to this article. This commentary does not contain a discussion of an unapproved/investigative use of a commercial product/device.

Presentation

A 2-month-old girl presents to her pediatrician for a regular checkup. Failure to gain weight, unmet developmental milestones, and hypotonia are observed, and the patient is admitted for evaluation for failure to thrive. The patient was born by spontaneous vaginal delivery at 39 weeks with a body weight of 2,690 g. Her newborn screening test result was normal. Shortly after birth, she was noted to have left buphthalmos associated with increased intraocular pressure (IOP) and underwent left eye trabeculotomy 10 days after birth. Postoperatively, she experienced hypothermia to 91.4°F (33.0°C), an elevated ammonia level to 126 μg/dL with mild metabolic acidosis, and difficulty regaining consciousness. She was admitted to the hospital for observation, and her ammonia level returned to normal without treatment. No further evaluation was initiated because the hyperammonemia self-corrected and was thought to be a postoperative complication related to anesthesia. She is currently followed by a glaucoma specialist. At home, she eats 2 to 3 oz of partially hydrolyzed cow milk formula every 3 hours, including overnight, an average of 101 to 151 kcal/kg per day. She has had no vomiting, diarrhea, or difficulty breathing. Her family history includes healthy parents, who both repeated a year of elementary school and received special education, and 2 healthy older brothers. Her extended family history includes a maternal grandmother who had 1 term stillbirth and 1 miscarriage and a developmentally normal 2-year-old maternal first cousin with a history of congenital cataracts. On physical examination, she is afebrile and her pulse is 152 beats/min, respiratory rate is 32 breaths/min, length is 20 in (52 cm) (2.20 percentile), weight is 3,170 g …

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Pediatrics in Review: 38 (4)
Pediatrics in Review
Vol. 38, Issue 4
1 Apr 2017
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Case 6: Failure to Thrive with Congenital Glaucoma in a 2-month-old Girl
Brittney Statler, David J. Massop, John W. Schmidt
Pediatrics in Review Apr 2017, 38 (4) 189-190; DOI: 10.1542/pir.2016-0132

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Case 6: Failure to Thrive with Congenital Glaucoma in a 2-month-old Girl
Brittney Statler, David J. Massop, John W. Schmidt
Pediatrics in Review Apr 2017, 38 (4) 189-190; DOI: 10.1542/pir.2016-0132
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  • Tachypnea and Epistaxis in a Full-term Infant
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