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Index of Suspicion

Case 4: Persistent Lung Lesion in a 6-year old Boy with Sickle Cell Disease

Ahmar U. Zaidi, Meret Henry and Michael U. Callaghan
Pediatrics in Review September 2018, 39 (9) 473-475; DOI: https://doi.org/10.1542/pir.2017-0084
Ahmar U. Zaidi
*Department of Hematology/Oncology, Children’s Hospital of Michigan, Detroit, MI
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Meret Henry
*Department of Hematology/Oncology, Children’s Hospital of Michigan, Detroit, MI
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Michael U. Callaghan
*Department of Hematology/Oncology, Children’s Hospital of Michigan, Detroit, MI
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  1. Ahmar U. Zaidi, MD*
  2. Meret Henry, MD, MS*
  3. Michael U. Callaghan, MD*
  1. *Department of Hematology/Oncology, Children’s Hospital of Michigan, Detroit, MI
  • AUTHOR DISCLOSURE

    Drs Zaidi and Henry have disclosed no financial relationships relevant to this article. Dr Callaghan has disclosed that he is involved in a Pfizer-funded investigator-initiated research study of sickle cell disease; that he is site principal investigator for 4 studies by Genentech and for studies by Sancillo and Global Blood Therapeutics; that he receives honoraria from Bayer, Shire, Novo Nordisk, and Genentech for speaking engagements; that he has participated in advisory boards for Shire, Genentech, Pfizer, Bayer, and Grifols; and that he owns stock in Alnylam. This commentary does not contain a discussion of an unapproved/investigative use of a commercial product/device.

Presentation

A 6-year-old boy with sickle cell disease (hemoglobin SS), who is on a long-term exchange transfusion program for repeated splenic sequestration and abnormal transcranial Doppler findings, presents to the emergency department with upper respiratory symptoms and a sore throat. On physical examination he appears well. His temperature is 99.3°F (37.4°C), heart rate is 100 beats/min, respiratory rate is 18 breaths/min, blood pressure is 110/65 mm Hg, and oxygen saturation is 100% on room air. A chest radiograph shows a lesion in the left upper lobe (Fig 1), thought to be round pneumonia, and the child is started on cefepime and azithromycin. It is noted that a very similar lesion was seen on …

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Pediatrics in Review: 39 (9)
Pediatrics in Review
Vol. 39, Issue 9
1 Sep 2018
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Case 4: Persistent Lung Lesion in a 6-year old Boy with Sickle Cell Disease
Ahmar U. Zaidi, Meret Henry, Michael U. Callaghan
Pediatrics in Review Sep 2018, 39 (9) 473-475; DOI: 10.1542/pir.2017-0084

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Case 4: Persistent Lung Lesion in a 6-year old Boy with Sickle Cell Disease
Ahmar U. Zaidi, Meret Henry, Michael U. Callaghan
Pediatrics in Review Sep 2018, 39 (9) 473-475; DOI: 10.1542/pir.2017-0084
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