Skip to main content

Advertising Disclaimer »

Main menu

  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors
    • Submit Manuscript
    • Author Guidelines
  • Content
    • Current Issue
    • Complete Issue PDF
    • Archive
    • Topic/Program Collections
    • Blog
  • Multimedia
    • Teaching Slides
    • Pediatrics On Call Podcast
  • CME/MOC
    • CME Quizzes
    • MOC Claiming
  • Subscribe
  • Alerts
  • Careers
  • Other Publications
    • American Academy of Pediatrics

User menu

  • Log in

Search

  • Advanced search
American Academy of Pediatrics

AAP Gateway

Advanced Search

AAP Logo

  • Log in
  • Journals
    • Pediatrics
    • Hospital Pediatrics
    • Pediatrics in Review
    • NeoReviews
    • AAP Grand Rounds
    • AAP News
  • Authors
    • Submit Manuscript
    • Author Guidelines
  • Content
    • Current Issue
    • Complete Issue PDF
    • Archive
    • Topic/Program Collections
    • Blog
  • Multimedia
    • Teaching Slides
    • Pediatrics On Call Podcast
  • CME/MOC
    • CME Quizzes
    • MOC Claiming
  • Subscribe
  • Alerts
  • Careers
American Academy of Pediatrics
Article

Use of C-Reactive Protein and Ferritin Biomarkers in Daily Pediatric Practice

Matthew D. Taylor, Vivek Allada, Michael L. Moritz, Andrew J. Nowalk, Rakesh Sindhi, Rajesh K. Aneja, Kathryn Torok, Michael J. Morowitz, Marian Michaels and Joseph A. Carcillo
Pediatrics in Review April 2020, 41 (4) 172-183; DOI: https://doi.org/10.1542/pir.2018-0101
Matthew D. Taylor
*Division of Critical Care Medicine, Cohen Children’s Medical Center of New York, New Hyde Park, NY
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vivek Allada
†Department of Pediatrics–Cardiology,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael L. Moritz
‡Department of Pediatrics–Nephrology,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrew J. Nowalk
§Department of Pediatrics–Infectious Diseases,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rakesh Sindhi
¶Pediatric Transplant Division, Department of Surgery,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Rajesh K. Aneja
**Department of Critical Care Medicine and Pediatrics,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Kathryn Torok
††Department of Pediatrics–Rheumatology, and
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael J. Morowitz
‡‡General Pediatric Surgery Division, Department of Surgery, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Marian Michaels
§Department of Pediatrics–Infectious Diseases,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joseph A. Carcillo
**Department of Critical Care Medicine and Pediatrics,
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • Comments
  • Quiz
Loading

This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.

Download PDF
  1. Matthew D. Taylor, MD*
  2. Vivek Allada, MD†
  3. Michael L. Moritz, MD‡
  4. Andrew J. Nowalk, MD, PhD§
  5. Rakesh Sindhi, MD¶
  6. Rajesh K. Aneja, MD**
  7. Kathryn Torok, MD††
  8. Michael J. Morowitz, MD‡‡
  9. Marian Michaels, MD, MPH§
  10. Joseph A. Carcillo, MD**
  1. *Division of Critical Care Medicine, Cohen Children’s Medical Center of New York, New Hyde Park, NY
  2. †Department of Pediatrics–Cardiology,
  3. ‡Department of Pediatrics–Nephrology,
  4. §Department of Pediatrics–Infectious Diseases,
  5. ¶Pediatric Transplant Division, Department of Surgery,
  6. **Department of Critical Care Medicine and Pediatrics,
  7. ††Department of Pediatrics–Rheumatology, and
  8. ‡‡General Pediatric Surgery Division, Department of Surgery, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA
  • AUTHOR DISCLOSURE

    Dr Taylor has disclosed that his spouse was a consultant for Corcept Therapeutics. Dr Aneja has disclosed that he receives royalties from UpToDate (Wolters Kluwer). Dr Michaels has disclosed that she receives support from Pfizer grant funding to her institution. Dr Carcillo has disclosed that he receives support from the National Institute of Child Health and Human Development (grant NICHD GM108618) via funding paid to his institution. Drs Allada, Moritz, Nowalk, Sindhi, Torok, and Morowitz have disclosed no financial relationships relevant to this article. This commentary does not contain a discussion of an unapproved/investigative use of a commercial product/device.

Abstract

Recent pediatric clinical research has begun to focus on risk stratification tools using multibiomarker models. C-reactive protein (CRP) and ferriti biomarkers are widely available and used to varying degrees in daily practice, but there is no single source examining the evidence behind their use.

We set out to summarize the evidence behind the use of CRP and ferritin biomarkers in pediatric practice and to begin development of a consensus for their future use for pediatricians.

All the literature involving CRP and ferritin in pediatrics available on PubMed was surveyed. Research applicable to daily pediatric practice was summarized in the body of the article. Pediatric clinicians of various subspecialties contributed to the summary of the use of CRP and ferritin biomarkers in clinical practice in various disease processes. A clinical decision pathway is described, and evidence is summarized.

CRP and ferritin biomarkers have diverse uses with various cutoff values in the literature, making their use in daily practice difficult. Elevation of these markers coincides with their significant elevation in uncontrolled inflammation.

CRP and ferritin biomarkers are widely used in pediatrics. This review provides a resource summarizing evidence into a single source. There is sufficient evidence to indicate that these biomarkers of inflammation can be useful in guiding clinical decision making in specific clinical scenarios; however, further work is needed to improve their use in clinical practice.

  • © American Academy of Pediatrics, 2020. All rights reserved.

Individual Login

Log in
You will be redirected to aap.org to login or to create your account.

Institutional Login

via Institution

You may be able to gain access using your login credentials for your institution. Contact your librarian or administrator if you do not have a username and password.

Log in through your institution

If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.

Pay Per Article - You may access this article (from the computer you are currently using) for 2 days for US$25.00

Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired.

Offer Reprints

PreviousNext
Back to top

Advertising Disclaimer »

In this issue

Pediatrics in Review: 41 (4)
Pediatrics in Review
Vol. 41, Issue 4
1 Apr 2020
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Complete Issue (PDF)
View this article with LENS
PreviousNext
Email Article

Thank you for your interest in spreading the word on American Academy of Pediatrics.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Use of C-Reactive Protein and Ferritin Biomarkers in Daily Pediatric Practice
(Your Name) has sent you a message from American Academy of Pediatrics
(Your Name) thought you would like to see the American Academy of Pediatrics web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Request Permissions
Article Alerts
Log in
You will be redirected to aap.org to login or to create your account.
Or Sign In to Email Alerts with your Email Address
Citation Tools
Use of C-Reactive Protein and Ferritin Biomarkers in Daily Pediatric Practice
Matthew D. Taylor, Vivek Allada, Michael L. Moritz, Andrew J. Nowalk, Rakesh Sindhi, Rajesh K. Aneja, Kathryn Torok, Michael J. Morowitz, Marian Michaels, Joseph A. Carcillo
Pediatrics in Review Apr 2020, 41 (4) 172-183; DOI: 10.1542/pir.2018-0101

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Quiz
Share
Use of C-Reactive Protein and Ferritin Biomarkers in Daily Pediatric Practice
Matthew D. Taylor, Vivek Allada, Michael L. Moritz, Andrew J. Nowalk, Rakesh Sindhi, Rajesh K. Aneja, Kathryn Torok, Michael J. Morowitz, Marian Michaels, Joseph A. Carcillo
Pediatrics in Review Apr 2020, 41 (4) 172-183; DOI: 10.1542/pir.2018-0101
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
Print
Download PDF
Insight Alerts
  • Table of Contents

Jump to section

  • Article
    • Abstract
    • Practice Gap
    • Objectives
    • Introduction
    • CRP Elevation
    • Ferritin Elevation
    • Combined Ferritin and CRP Elevation
    • Clinical Decision Pathway for Elevated CRP and Ferritin Levels
    • Conclusions
    • References
  • Figures & Data
  • Info & Metrics
  • Comments
  • Quiz

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Review of Scabies Infestation and Selected Common Cutaneous Infections
  • Pediatric Ingestions: New High-Risk Household Hazards
  • Iron Deficiency: Implications Before Anemia
Show more Articles

Similar Articles

Subjects

  • Infectious Disease
    • Infectious Disease
  • Critical Care
    • Critical Care
  • Journal Info
  • Editorial Board
  • ABP Content Specifications Map
  • Overview
  • Licensing Information
  • Authors
  • Author Guidelines
  • Submit My Manuscript
  • Librarians
  • Institutional Subscriptions
  • Usage Stats
  • Support
  • Contact Us
  • Subscribe
  • Resources
  • Media Kit
  • About
  • International Access
  • Terms of Use
  • Privacy Statement
  • FAQ
  • AAP.org
  • shopAAP
  • Follow American Academy of Pediatrics on Instagram
  • Visit American Academy of Pediatrics on Facebook
  • Follow American Academy of Pediatrics on Twitter
  • Follow American Academy of Pediatrics on Youtube
American Academy of Pediatrics

© 2021 American Academy of Pediatrics