Table 1.

Relative Frequency of Clinical Conditions in Untreated Human Immunodeficiency Virus Infection

SPECIFIC CONDITIONS IN BODY SYSTEM OR ILLNESS CATEGORYaRELATIVE FREQUENCY
Infections: recurrent, severe, or unusual (opportunistic)
 Recurrent or chronic otitis, sinusitisCommon
 Recurrent or severe pneumoniaCommon
 Recurrent or severe bacteremiaCommon
 Opportunistic infections, such as PCP, MAC, invasive candidal infectionsCommon
Lymphoreticular system
 Generalized lymphadenopathyCommon
 HepatomegalyCommon
 SplenomegalyCommon
 Parotid enlargementCommon
 Lymphoid interstitial pneumonitisCommon
Growth
 Failure to thriveCommon
 Weight loss, wastingCommon
 StuntingCommon
 Delayed pubertyCommon
Neurologic
 Neurodevelopmental delay or regressionCommon
 Abnormal tone (increased or decreased)Common
 Gait disturbanceCommon
 Peripheral neuropathyUncommon
 StrokeUncommon
Pulmonary
 Bacterial pneumoniaCommon
 Lymphoid interstitial pneumonitisCommon
 BronchiectasisUncommon
 PneumothoraxUncommon
Cardiovascular
 CardiomyopathyUncommon
 Pericardial effusionUncommon
 Conduction abnormalitiesUncommon
 HypertensionUncommon
 VasculopathyUncommon
Gastrointestinal
 GastritisCommon
 DuodenitisCommon
 HepatitisUncommon
 PancreatitisUncommon
 CholecystitisUncommon
 DiarrheaCommon
 Gastrointestinal bleedingUncommon
 Abdominal painCommon
Renal
 ProteinuriaCommon
 Renal tubular acidosisUncommon
 Renal failureUncommon
 HypertensionUncommon
Hematologic
 AnemiaCommon
 NeutropeniaCommon
 ThrombocytopeniaCommon
Dermatologic
 SeborrheaCommon
 EczemaCommon
 UrticariaUncommon
 ZosterCommon
 Herpes simplex infectionsCommon
 Tinea corporis, capitis, unguiumCommon
 Bacterial infectionsCommon
 Molluscum contagiosumCommon
 Warts (HPV)Common
Genital or reproductive
 HPV-related dysplasia (cervical, anal)Common
 Pelvic inflammatory diseaseCommon
 Delayed pubertyCommon
  • HPV=human papillomavirus, MAC=Mycobacterium avium complex, PCP=Pneumocystis jiroveci pneumonia.

  • a Some conditions belong to more than one category.

  • Adapted from Simpkins et al. (21)