Table 4.

Neonatal ARV Drug Dosing for Prevention of Mother-to-Child Transmission of HIV

ARV DRUG AND DOSEDURATION
Zidovudine should be given to ALL HIV-exposed newborns and should be started as soon after birth as possible, preferably within 6–12 hours of delivery
≥35 weeks’ gestation at birth: 4 mg/kg orally twice daily (if unable to tolerate oral agents, 3 mg/kg/dose intravenously, beginning within 6–12 hours of delivery, then every 12 hours)Birth through 6 weeks
≥30 to <35 weeks’ gestation at birth: 2 mg/kg orally (or 1.5 mg/kg intravenously) every 12 hours, advanced to 3 mg/kg orally (or 2.3 mg/kg intravenously) every 12 hours at age 15 daysBirth through 6 weeks
<30 weeks’ gestation at birth: 2 mg/kg orally (or 1.5 mg/kg intravenously) every 12 hours, advanced to 3 mg/kg orally (or 2.3 mg/kg intravenously) every 12 hours after age 4 weeksBirth through 6 weeks
Nevirapine administered in addition to zidovudine to newborns of HIV-infected women who received no antepartum ARV prophylaxis
Weight band dosingThree doses in the first week of life
Birth weight 1.5–2 kg: 8 mg for each doseaFirst dose within 48 hours of birth (as soon after birth as possible)
Birth weight >2 kg: 12 mg for each doseaSecond dose 48 hours after first
Third dose 96 hours after second
  • ARV=antiretroviral; HIV=human immunodeficiency virus.

  • Adapted from AIDS Info. (11)

  • a Nevirapine dosing given as actual doses not as milligram per kilogram dosing.