Table 3.

Recommended Routes and Durations of Treatment for Lyme Disease

Clinical Manifestations by Disease StageTreatmentDuration, d
Early localized disease
 Erythema migransOral14–21a
Early disseminated disease
 Multiple erythema migransOral14–21
 Isolated cranial nerve palsyOral14–21
  HospitalizedIntravenous followed by oralc14–21
Late disease
 Recurrent or persistent arthritis after oral therapyOral or intravenous28
  • a Doxycycline may be administered for 10 days in uncomplicated cases.

  • b Doxycycline may be substituted after symptoms have resolved.

  • c At the time of discharge, the patient may receive oral medication to complete therapy.