Table 4.

Recommended Drugs and Doses for Treatment of Lyme Disease

TreatmentAdult DosePediatric Dose
Oral therapy
 Doxycycline (Patients ≥8yrs)100 mg4 mg/kg/day
2 times per dayDivided 2 times per day
(up to 100mg/dose)
 Amoxicillin500 mg50mg/kg/day
3 times per dayDivided 3 times per day
(up to 500mg/dose)
 Cefuroxime axetil500 mg30 mg/kg/day
2 times per dayDivided 2 times per day
(up to 500mg/dose)
Intravenous therapy
 Ceftriaxone2g50-75 mg/kg/day
1 time per day(up to 2g/dose)
1 time per day
 Cefotaxime2g150-200 mg/kg/day
Every 8 hours(up to 2g/dose)
Every 8 hours