Table 2.

Diabetes Prevention Trial—1

Screening
• ICA measurement (or two other autoantibodies)
— First-degree relatives: siblings, parents, children ages 3 to 45 years
— Second-degree relatives: cousins, nieces, nephews, aunts, uncles ages 3 to 20 years
Staging
• Genetic: protective HLA*0602-positive subjects excluded
• Immunologic: IAA
• Metabolic: IVGTT for FPIR
Intervention
• High risk (>50% risk of diabetes in 5 years): parenteral insulin
• Moderate risk (25% to 50% risk of diabetes in 5 years): oral insulin
  • HLA = human lymphocyte antigen, IAA = insulin autoantibodies, IVGTT = intravenous glucose tolerance testing, FPIR = first-phase insulin release.