Table 1.

Genetic, Environmental, and Immunologic Susceptibility and Protective Factors

SUSCEPTIBILITYPROTECTION
GeneticDRDR3/4DR2/5
DQB10302/02010602
DQA10301/05010102
EnvironmentalCoxsackieCertain viruses
TriggersMumps
Congenital rubella
ImmunologicTh1Th2
IL-1, TNF alpha, IFNIL-4
  • Th = T helper cell, IL = interleukin, TNF = tumor necrosis factor, IFN = interferon.