Pathogenic Factors of the Anemia of Chronic Renal Failure

Decreased erythropoiesis
• Reduced availability of erythropoietin
• Inhibitor(s) of erythropoiesis*
• Bone marrow fibrosis*
Shortened red blood cell survival*
• Hemolysis due to extracorpuscular factor(s)
Excessive blood losses
Deficiency states
• Iron deficiency
• Folic acid deficiency
  • * These factors seem to be exacerbated by hyperparathyroidism.