TABLE 7.

Clinical Features of Renal Osteodystrophy in Childhood

Clinical manifestations
• Growth retardation
• Bone pain
• Myopathy
• Skeletal deformities
• Rickets signs in infants
Biochemical data
• Increased serum AP activity
• Elevated serum PTH concentrations
• Lower serum 1,25-(OH)2-D3
Radiologic abnormalities
• Subperiosteal resorption
• Epiphyseal slipping
• Osteopenia
Pathologic findings
• Osteitis fibrosa
  • AP = alkaline phosphatase, PTH = parathyroid hormone, 1,25-(OH)2-D3 = 1,25-dihydroxyvitamin-D3